Technology Overview

EKOS® has developed a proprietary catheter-based drug delivery system that combines the use of targeted drug delivery catheters and the therapeutic benefits of a high frequency low power microsonic energy.

How EKOS MicroSonic™ Accelerated Thrombolysis Unlocks The Clot

Without microsonic energy, the fabric of a blood clot, called fibrin, is tightly bound (figure 1). The microsonic energy helps temporarily loosen and separate the fibrin (figure 2) for more blood clot permeability. Loosened fibrins increases the availability of more plasminogen activation receptor sites (figure 3). At the same time, the microsonic energy helps drive the thrombolytic agents deep into the blood clot to accelerate the thrombolysis, and ultimately dissolve the clot.

figure 1 figure 2 figure 2

Dual action of the EKOS® microsonic energy enhanced delivery systems provides the following advantages:

  • Microsonic energy thins the fibrins making the thrombus more permeable to the thrombolytic drug.
  • Drives thrombolytic drugs into the loosened clot.
  • No reported fragmentated emboli often associated with more aggressive mechanical techniques.
  • No reported hemolysis, a complication often associated with mechanical devices.
  • Reduces fluoroscopy time.
  • Minimizes need for attention from hospital staff because the system self regulates and optimizes the power of the microsonic energy delivered.

New EkoSonic™ Endovascular System with Rapid Pulse™ Modulation

In Laboratory in vitro testing, the EkoSonic system dissolved thrombus twice as fast as earlier EKOS systems - and four times faster than conventional catheter - directed thrombolysis. With no evidence of thrombus breakage. And no hemolysis.

The EkoSonic™ Endovascular System is intended for the controlled and selective infusion of physician – specified fluids including thrombolytics, into the peripheral vasculature. The EkoSonic™ Endovascular System is also intended for the infusion of solutions into the Pulmonary Arteries.

The Safety and effectiveness of the EkoSonic™ Endovascular System for thrombolytic therapy administration in pulmonary embolus have not been established. In particular, the ultrasound energy delivered by the EkoSonic System is not intended to be therapeutic, nor has it been cleared with an indication for thrombolysis in pulmonary emboli. 

With Rapid Pulse™ Modulation

The innovation behind this breakthrough is EKOS Rapid Pulse™ Modulation, which manipulates the amplitude and duration of the microsonic energy released into the clot to optimize its impact. In laboratory tests with identical samples, Rapid Pulse Modulation demonstrated greater clot permeability and drug penetration, resulting in accelerated dissolution.

EkoSonic™ Mach 4 Endovascular Device
EkoSonic™ Mach 4 Endovascular Device

New EkoSonic™ Mach 4 Endovascular Device is precision calibrated to work exclusively with the EkoSonic Control Unit and its Rapid Pulse Modulation Technology.

  • Four Times Faster Than Catheter - Directed Thrombolysis
  • Increased Clot Permeability And Drug Penetration
  • No Evidence of Thrombus Breakage Or Hemolysis
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