now with MACH4e
the standard for safety and
dissolving clots with its first generation of
ultrasound thrombolytic technology.
It raised the bar with MACH4. And now, EKOS
scientists have refined the performance yet again
with MACH4e; up to 40% faster1 than MACH4.
With no evidence of thrombus breakage2. And no
hemolysis3. Less time to complete dissolution means
a lower lytic drug dosage.
And that means an even
lower risk of complications.
A preferred alternative to current therapies
EkoSonic acoustic energy conditions clot by
thinning fibrin, increasing porosity and
creating a pressure gradient which transports
clot dissolving drug deep inside the occluding
Penetrates thrombus, in difficult–to-reach
places, such as behind valves4
- Uses 50 - 70% less lytic drug4
- No thrombus fracture or breakage2, reducing the
risk of distal embolism
- Exposes thrombus to greater drug uptake5
- Captures drug within thrombus5
- No damage to valves3
or the vascular wall
- No hemolysis3. Does not fracture red blood
cells, so there is no adenosine release and no additional compromise to renal
- Higher level of vessel patency,
thrombus more completely, possibly reducing the
risk of Post-Thrombotic Syndrome (PTS)
- Shortest physician lab time
is intended for controlled and selective
infusion of physician-specified fluids,
including thrombolytics, into the peripheral vasculature.
Contraindications* Not designed for peripheral
vasculature dilation purposes.* This system is
contraindicated when, in the medical judgment of the physician, such
procedure may compromise the patient’s
Vasculature: Both the EkoSonic Endovascular System
and the EkoSonic
SV Endovascular Systems are
intended for controlled and selective infusion
of physician-specified fluids, including thrombolytics, in the peripheral vasculature.
vitro data on file
Braaten, J., Goss, R., Francis, C. “Ultrasound
Reversibly Disaggregates Fibrin Fibers.” Thromb
Haemost 78 (1997) 1063-8.4.
Soltani, A., et al “Absence of biological damage
from prolonged exposure to intravascular
ultrasound.” Ultrasonics 46 (2007) 60-67
Parikh, S., et al. Ultrasound-Accelerated Thrombolysis for the Treatment of Deep Vein
Thrombosis: Initial Clinical Experience. Journal of
Interventional Radiology, April, 2008, 19:4,
Francis, CW. et al. “Ultrasound Accelerates
Transport of Recombinant Tissue Plasminogen
Activator into Clots.” Ultrasound in Medicine and
Biology, 21.3 (1995): 419-424
Soltani A, Volz KR, Hansmann
DR. “Effect of modulated ultrasound parameters
on ultrasound-induced thrombolysis”. Phys Med Biol.
2008. Phys Med Biol, 2008