Clinical
Benefits
A Preferred Alternative To Current Therapies
EKOS ultrasonic accelerated thrombolysis offers
significant benefits over previously used methods of
treatment for thrombus. Unlike systemic
anticoagulation therapy, it actually dissolves
clots, which most likely reduces the risk of
post-thrombotic syndrome. Like catheter-directed
thrombolysis, the simple EKOS endovascular device
can be placed across the occlusive lesion in
minutes, minimizing cath lab time. In addition, EKOS
offers significant additional clinical advantages
including:
- Successfully treats thrombi
in difficult to reach places, such as behind
valves
- Requires significantly
shorter treatment times, typically less than
half to one quarter of CDT2
- Uses a lower lytic drug
dosage
- Does not fracture or break
the thrombus, hence reducing the risk of distal
embolism4,5
- Does not fracture red blood
cells, resulting in no adenosine release and no
additional compromise to renal function6
- Results in complete
dissolution of obstructive thrombus and requires
no follow up afterward with catheter-directed lytic
- Requires less time in the
cath lab7
2Parikh,
S., Motarjeme, A., et. al. “Ultrasound-Accelerated
Thrombolysis for the Treatment of Deep Vein
Thrombosis: Initial Clinical Experience”. Journal of
Vascular and Interventional Radiology, Volume 19,
Issue 4, April 2008, pp 521-528.
3Wissgott,
Christian, et al. Treatment of Critical Limb
Ischemia Using Ultrasound-Enhanced Thrombolysis
(PARES Trial): Final Results, Jrnl of Endovascular
therapy. 14:4, August 2007 438-443
4Braaten, J., Goss, R., and Francis, CW.
“Ultrasound Reversibly Disaggregates Fibrin Fibers.”
Thromb Haemost 78 (1997) 1063-8.
5Francis, Charles W. et al. “Ultrasound
Accelerates Transport of Recombinant Tissue
Plasminogen Activator into Clots.” Ultrasound in
Medicine and Biology 21.3 (1995): 419-424.
6Soltani, A., et al “Absence of
biological damage from prolonged exposure to
intravascular ultrasound.” Ultrasonics 46 (2007)
60-67.
7Cynamon, J., et al. “A New Method for
Aggressive Management of Deep Vein Thrombosis:
Retrospective Study of the Power Pulse Technique”.
Journal of Vascular Interventionology, 2006;
17:1043-49 |
