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Healthcare Professionals    

 

Clinical Benefits

A Preferred Alternative To Current Therapies

EKOS ultrasonic accelerated thrombolysis offers significant benefits over previously used methods of treatment for thrombus. Unlike systemic anticoagulation therapy, it actually dissolves clots, which most likely reduces the risk of post-thrombotic syndrome. Like catheter-directed thrombolysis, the sophisticated EKOS endovascular device can be placed across the occlusive lesion in minutes, minimizing cath lab time. The ultrasound feature of  EKOS offers significant additional clinical advantages including:

  • Successfully treats thrombi in difficult to reach places, such as behind valves
     
  • Requires significantly shorter treatment times, typically less than half to one quarter of CDT2
     
  • Uses a lower lytic drug dosage
     
  • Does not fracture or break the thrombus, hence reducing the risk of distal embolism4,5
     
  • Does not fracture red blood cells, resulting in no adenosine release and no additional compromise to renal function6
     
  • Results in complete dissolution of obstructive thrombus and requires no follow up afterward with catheter-directed lytic
     
  • Requires less time in the cath lab7 and less radiation exposure to lab staff.

2Parikh, S., Motarjeme, A., et. al. “Ultrasound-Accelerated Thrombolysis for the Treatment of Deep Vein Thrombosis: Initial Clinical Experience”. Journal of Vascular and Interventional Radiology, Volume 19, Issue 4, April 2008, pp 521-528.

3Wissgott, Christian, et al. Treatment of Critical Limb Ischemia Using Ultrasound-Enhanced Thrombolysis (PARES Trial): Final Results, Jrnl of Endovascular therapy. 14:4, August 2007 438-443

4Braaten, J., Goss, R., and Francis, CW. “Ultrasound Reversibly Disaggregates Fibrin Fibers.” Thromb Haemost 78 (1997) 1063-8.

5Francis, Charles W. et al. “Ultrasound Accelerates Transport of Recombinant Tissue Plasminogen Activator into Clots.” Ultrasound in Medicine and Biology 21.3 (1995): 419-424.

6Soltani, A., et al “Absence of biological damage from prolonged exposure to intravascular ultrasound.” Ultrasonics 46 (2007) 60-67.

7Cynamon, J., et al. “A New Method for Aggressive Management of Deep Vein Thrombosis: Retrospective Study of the Power Pulse Technique”. Journal of Vascular Interventional Radiology, 2006; 17:1043-49

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